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Serum samples were collected from healthy children 0—18 years old. The renal marker CysC did not substantially change after 1 year old.
Cr, urea, and UA levels generally increased with age. These intervals need to be partitioned by age and sex. At present, serum creatinine Cr and cystatin C CysC levels are often used as reference indices for evaluating glomerular filtration function. However, serum Cr levels can be affected by non-renal factors, such as muscle mass, age, and sex.
This study enrolled children 0—18 years old who had a routine physical examination in the Department of Child Health at the Affiliated Hospital of Zunyi Medical University between June and March All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the Affiliated Hospital of Zunyi Medical University No.
Flow chart showing all recruited participants, including those excluded from the study. The participants fasted for 6 to 12 hours before a health examination. The indirect immunofluorescence method was used to detect serum CysC levels trueness: relative bias, 1.
The serum CysC detection kit was purchased from Gensource Co. Shanghai, China and the instrument parameters were set strictly in accordance with the reagent instructions. The CysC assay was calibrated using the Gensource self-contained calibrator batch number: A and the matrix was human serum. Low-value and high-value serum quality control materials that were obtained from Gensource were used for quality controls.